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  • 9 January 2020 21:58

Downstream Processing Market Hit USD 40.1 billion by 2026

The global downstream processing market value is expected to reach around USD 40.1 billion by 2026

The global downstream processing market value is expected to reach around USD 40.1billion by 2026, this market is anticipated to grow with 14.0% CAGR during the forecast time period. Surge in acceptance and adoption of biotech processes in the agricultural, pharmaceutical, and bio-services industries is anticipated to boot the market over the forthcoming years.

Downstream processing is an important aspect of drug manufacturing, especially for vaccines, monoclonal antibodies, hormones, antibiotics, enzymes, and antibodies. The process involves recovery and purification of pharmaceuticals from animal, plant, or any other natural source.

Rapid growth of the biotechnology sector is one of the key trends fueling the demand for downstream processing. This is majorly due to high adoption of biotech processes in the pharmaceutical, agricultural, and bio-services industries. In addition, developments in the field of gene therapy and genetic engineering are estimated to propel the market during the forecast period.

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Efforts are being taken by major players to streamline the process and cut-down the overall procedure cost, which will subsequently reduce the overall price of the product. This is leading to increase in investments in biotech R&D and evolution of new downstream processing technologies that allow high throughput and have short processing time.

Some of the promising downstream processing techniques are membrane affinity chromatography, perfusion chromatography, single use systems, and employment of high throughput process development. Moreover, product quality constraints, regulatory directives, and increased titers are further encouraging advancements in downstream processing.

Growing investments in the development of bioprocess and fermentation technologies to support large scale production of biologics and biosimilar are expected to spur the growth of the market. Scope for the usage of downstream processing technique for commercial production of biosimilars has been expanding owing to rising demand for biosimilars.

Biopharmaceuticals are emerging as new paradigms for blockbuster medications and their sales are spiraling, despite their high costs. Therefore, due to high capital profits offered by biopharmaceuticals, major pharma manufacturers are increasingly shifting their R&D activities to biopharma.

Contract manufacturing organizations (CMOs) are playing a significant role in the growth of the market. A new biopharma plant, which is to be equipped with large stainless-steel bioreactors to produce high-volume biopharmaceuticals, requires nearly more than $250 million and a minimum lead time of four years. Therefore, new market entrants, start-ups, and some large pharma companies expanding their pipeline to biopharma switch to CMOs rather than building up their own production capacity.

Moreover, a strong pipeline of biologics including viral vectors, multispecific monoclonal antibodies, peptides, and oligonucleotides requires transformation of biopharma plants into multi-modality and multi-platform units. However, most of these plants are still in mono-platform and mono-modality setup. Thus, in this situation, contract manufacturing becomes an optimal choice for commercial production of biologics without increasing manufacturing costs.

Increasing adoption of integrated solutions, wherein a single company offers each individual component of the downstream system such as instrument, consumables, technical support, validation, and training services, is a significant trend observed in this marketspace. This helps in a better product recovery and avoids any loss due to several steps in conventional production. Some of the major providers of integrated solutions are Merck KGaA (Merck Millipore) and General Electric Company (Amersham Biosciences).

The global downstream processing market is segmented into four major segment named product, technique, application, and region. On the basis of product the downstream processing market is segmented into chromatography systems, filters, evaporators, centrifuges, dryers and others. On the basis of the technique the global downstream processing market is segmented into cell disruption, solid-liquid separation (filtration, centrifugation) concentration (evaporation, membrane filtration), and purification by chromatography and formulation. These solid-liquid separation are further bifurcated into filtration, and centrifugation, and the concentration is also further segmented evaporation, and membrane filtration. On the basis of application, the downstream processing market is segmented into antibiotic production, hormone production, antibodies production, enzyme production, and vaccine production. On the basis of region the global downstream processing market is segmented into North America, Europe, Asia Pacific, Latin America and Middle East & Africa.

Main market participants delivers safe and integrated chromatography solutions that work efficiently throughout all steps of a bioprocess. In current years, key vendors have established technologically competent systems that address emerging needs of the industry to accomplish state-of-the-art chromatography steps throughout manufacturing of bio-therapeutics. Such as, single-use chromatography is single of the most important inventions of the biopharmaceutical business.

Single-use chromatography eradicates the need for large-scale chromatography columns, resin storage, column packing, and storage of packed columns. The technology has also led to reduction in water and chemicals for cushion to as much as 80.0%. This safeguards augmented productivity and competence of bioprocess in less time and with abridged labor.

Filter manufacturers have been emerging progressive filters with high performance due to growing need for viral clearance. Viruses can brutally damage an entire process stream. There are numerous micro and ultra-filters commercially accessible in the market. A few instances of the same comprise of Viresolve filters from Merck Millipore, Planova virus removal filters from Asahi-Kasei, and Virosart brand from Sartorius Stedim Biotech.

Also, to virus clearance, sterile filtration is also deployment for removal of certain antibiotic resistant bacterial species for instance Mycoplasma. Filters deployment for this purpose comprise of Millipore Express from Merck, Nalgene PES filters and Fluorodyne from Pall Corporation (Danaher).

Antibodies are one of the most major modalities obtainable by the biopharmaceutical sector today. This accomplishment is due to establishment of robust manufacturing platforms that generate high titers for monoclonal antibodies in mammalian cell cultures.

Also, development of certain new methods in bio processing of antibodies have additional increased the market. These new methods comprise of constant alternative expression systems, bio manufacturing, and non‐chromatographic separation formats.

Furthermore, as antibiotic resistance is on increase, there is asurge in need for growth of antibodies that act against resistant strains. This, in turn, is growing the need for downstream processing for antibody production at industrial scale.

North America captures the largest the global downstream processing market in 2018. The development of the region can be attributed to augmented focus of government bodies on the growth of the biotechnology industry, increasing healthcare expenditure, and occurrence of adequate infrastructure for development and growth of bio processing industries. Due to recent progressions, there is a considerable increase in sales of biotechnology products in the region. Consequently, continual innovations in the biotechnology sector are possible to deliver plenty development opportunities to the regional market during the forecast timeframe.

Key players

The key players operating in the global downstream processing market are General Electric Company (GE Healthcare), Thermo Fisher Scientific Inc., Merck KGaA (Merck Millipore), Sartorius Stedim Biotech S.A., and Danaher Corporation. Some other players catering to the market are Dover Corporation (CPC (Colder Products Co.)), Repligen, Boehringer Ingelheim International GmbH, 3M Company, Eppendorf AG, Corning Corporation, Ashai Kasei, Lonza Group Ltd, and Ferner PLC. These market player are investing massive wealth to transform the product line as the rivalry in the market is increasing with rapid pace. Likewise, with varying technology the need for better technology infrastructures are rising, so cater the need of the customers, market participants are continuously inventing new products.

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Market Segmentation Market By Product

  • Chromatography Systems
  • Filters
  • Evaporators
  • Centrifuges
  • Dryers
  • Others
Market By Application
  • Cell Disruption
  • Solid-liquid separation
    • Filtration
    • Centrifugation
  • Concentration
    • Evaporation
    • Membrane filtration
  • Purification by Chromatography
  • Formulation
Market By Technique
  • Antibiotic Production
  • Hormone Production
  • Antibodies Production
  • Enzyme Production
  • Vaccine Production
Market By Geography
  • North America
    • U.S.
    • Canada
    • Mexico
  • Europe
    • UK
    • Germany
    • France
    • Rest of Europe
  • Asia-Pacific
    • China
    • Japan
    • India
    • Australia
    • Rest of Asia-Pacific
  • Latin America
    • Brazil
    • Chile
    • Rest of Latin America
  • Middle East and Africa (MEA)
    • South Africa
    • Saudi Arabia
    • Rest of MEA

The study objectives of this report are:

- To analyze and study the global market capacity, production, value, consumption, status (2014-2018) and forecast (2019-2026);

- Focuses on the key manufacturers, to study the capacity, production, value, market share and development plans in future.

- Comprehensive company profiles covering the product offerings, key financial information, recent developments, SWOT analysis, and strategies employed by the major market players

- To define, describe and forecast the market by type, application and region.

- To analyze the global and key regions market potential and advantage, opportunity and challenge, restraints and risks.

- To identify significant trends and factors driving or inhibiting the market growth.

- To analyze the opportunities in the market for stakeholders by identifying the high growth segments.

- To strategically analyze each submarket with respect to individual growth trend and their contribution to the market

- To analyze competitive developments such as expansions, agreements, new product launches, and acquisitions in the market

- To strategically profile the key players and comprehensively analyze their growth strategies.

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